Research Assets
The Research Assets category provides summaries of scientific studies and evidence-based insights that support the information found in Bernie’s University. Each asset highlights key findings, practical applications, and how the research relates to canine health, nutrition, and wellness, helping pet parents make informed decisions backed by science.
Last Reviewed Date: 01/21/25
| Featured Image | ID | Title | Link | Status | At a Glance |
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249,037 | Therapeutic Effect of EPA and DHA Supplementation in Neoplastic and Non-Neoplastic Companion Animal Diseases | https://www.bernies.com/?post_type=bu-research-paper&p=249037 | publish | This systematic review evaluates the therapeutic effects of EPA and DHA in treating various diseases in dogs and cats. Twenty-three randomized studies were analyzed, with benefits seen in both neoplastic (cancer-related) and non-neoplastic conditions such as allergic dermatitis, osteoarthritis, cardiovascular diseases, and haircoat disorders. The anti-inflammatory and immunomodulatory properties of EPA and DHA, through suppression of pro-inflammatory cytokines and matrix metalloproteinases, are highlighted as key mechanisms for their therapeutic effects. |
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253,238 | Research Asset Template Article | https://www.bernies.com/?post_type=bu-research-paper&p=253238 | publish | This research paper tells us lots of things about lots of things. This summary is 1-3 sentences and also appears in the “at a glance” column on related pages. |
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261,248 | The vital roles of boron in animal health and production: A comprehensive review. | https://www.bernies.com/?post_type=bu-research-paper&p=261248 | publish | This scientific review, published in the Journal of Trace Elements in Medicine and Biology (2018) by Abdelnour et al., explores how boron influences bone health, immune function, metabolism, and overall physiological processes in various animal species. While dogs are not included in the study, the findings provide valuable insights into boron's role in mammalian skeletal and metabolic health, suggesting potential relevance for canines. |
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261,249 | Anti-inflammatory and anti-arthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models | https://www.bernies.com/?post_type=bu-research-paper&p=261249 | publish | This 2008 laboratory study investigated whether piperine, the active compound in black pepper, could help reduce inflammation and joint damage in arthritis. Researchers tested piperine on human joint cells from arthritis patients and rats with induced arthritis to observe its effects on inflammatory pathways and pain response. The results showed that piperine reduced key inflammatory markers (IL-6, PGE2) and enzymes that contribute to cartilage breakdown (MMP-13, COX-2). Rats treated with piperine also experienced less joint swelling, improved movement, and reduced pain sensitivity. |
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261,250 | Vitamin C protects chondrocytes against monosodium iodoacetate-induced osteoarthritis by multiple pathways | https://www.bernies.com/?post_type=bu-research-paper&p=261250 | publish | This 2016 laboratory study in rats and human-derived cell cultures investigated whether vitamin C could help protect cartilage from osteoarthritis (OA)-related damage. The study found that vitamin C reduced oxidative stress, inflammation, and cartilage breakdown in a rat model of OA, suggesting potential benefits. However, this research was not conducted in dogs, so its relevance to canine health is uncertain. Interestingly, higher doses of vitamin C were not more effective, meaning there may be an optimal amount beyond which additional vitamin C does not provide extra protection. |
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261,251 | The effect of vitamin C supplementation in healthy dogs on antioxidative capacity and immune parameters | https://www.bernies.com/?post_type=bu-research-paper&p=261251 | publish | This 2009 study investigated the effects of vitamin C supplementation on antioxidative capacity and immune function in healthy dogs. While the study, conducted with only 15 dogs, found no significant benefits in oxidative stress markers or immune response, it provides valuable context for understanding vitamin C’s role in canine health. The findings suggest that vitamin C supplementation may be unnecessary in well-nourished dogs with sufficient vitamin E intake but highlight areas where further research is needed—especially in dogs facing oxidative stress, illness, or aging. |
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261,252 | Vitamin C in Health and Disease: A Companion Animal Focus | https://www.bernies.com/?post_type=bu-research-paper&p=261252 | publish | This 2020 review article explores the role of vitamin C in companion animal health, focusing on its synthesis, functions, and potential therapeutic applications. While dogs and cats can produce their own vitamin C, the review discusses how levels may decrease in certain diseases, raising questions about the benefits of supplementation. The study highlights vitamin C’s role in oxidative stress reduction, immune support, and critical illness management, suggesting it as a potential low-risk therapy for conditions like sepsis. |
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261,253 | The relationship between vitamin K and osteoarthritis: A review of current evidence | https://www.bernies.com/?post_type=bu-research-paper&p=261253 | publish | This 2020 review examines the relationship between Vitamin K status and osteoarthritis (OA), focusing on how Vitamin K influences cartilage calcification, inflammation, and joint degeneration. The findings suggest that sufficient Vitamin K levels may help slow OA progression by regulating proteins that prevent abnormal calcium buildup in joints. While the study focuses on human OA research, it may have implications for canine joint health and mobility. |
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261,254 | Vitamin K2 in animal health: An overview | https://www.bernies.com/?post_type=bu-research-paper&p=261254 | publish | This 2016 review explores Vitamin K2’s role in bone health, blood clotting, and overall physiology across animal species. While not focused on dogs, its findings on skeletal strength and disease prevention may have implications for canine health, particularly in aging or at-risk dogs. |
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261,255 | Regulation of bone remodeling by vitamin K2 | https://www.bernies.com/?post_type=bu-research-paper&p=261255 | publish | This article, published in Oral Diseases in 2017, reviews how Vitamin K2 regulates bone remodeling, the process of breaking down and rebuilding bone tissue. The findings suggest that Vitamin K2 supports bone density, reduces fracture risk, and may help prevent osteoporosis, especially when combined with Vitamin D3. The research primarily examines human, rat, and mouse models to understand Vitamin K2’s role in skeletal health. |